Objective: To characterize the clinical profiles and to detennine the relationship of drug - induced hypersensitivity syndrome (DIHS) with human herpes virus infection in children. Methods: Clinical characteristics of 25 children patients with DIHS were analyzed retrospectively and human herpes virus (HHV) genome of serum samples was detected by polymerase chain reaction in 6 patients. Results: Of the 25 patients, 17 was male and 8 female. Fifteen patients were younger than 3 years old. The most common causable drugs were anticonvulsive drug in 9 cases, antipyretic analgesics in 9, antibiotics in 4. Blood test revealed Eosinophilia in 17 cases, mononucleosis in 11, atypical lymphocytosis in 7, Liver dysfunction was found in 22 cases, Elevated myocardial enzyme was found in 17 cases and renal dysfunction in 4. HHV-6 genome was detected in 4 of 6 patients and HHV- 7 genome in 2.Conclusion: The most common reactive drugs were anticonvulsive drug, antipyretic analgesics and antibiotics in the current group of patients. DIHS in children may be related to HHV6 infection.%目的:分析儿童药物超敏综合征(DIHS)的临床特点及其与疱疹病毒(HHV)的相关性.方法:回顾性分析我院收治的DIHS病例资料,对其中6例做了血液HHV PCR检测.结果:25例患儿中男17例,女8例.3岁前发病15例.致敏药物分别为抗惊厥药9例;解热镇痛药9例;抗生素4例.实验室检查:嗜酸粒细胞计数升高17例,单核细胞计数升高11例,异型淋巴细胞7例;转氨酶升高22例,心肌酶升高17例,肾功能异常4例.血液HHV PCR DNA测定:6例中HHV6阳性4例,HHV7阳性2例,EB,HHV8和巨细胞病毒均为阴性.结论:儿童DIHS常见致敏药物为抗惊厥药、解热镇痛药和抗生素,其部分病例的发生可能与HHV6感染相关.
展开▼
