A new quad-modality integrated molecular imaging system for small animal was invented, which integrated the modalities of computed tomography (CT), positron emission tomography (PET), single-photon emission computed tomography (SPECT) and lfuorescent molecular tomography (FMT). The imaging results of mouse models of tumors and inflammation revealed that the multi-modality integrated comprehensive reconstruction can provide more structural, functional and metabolic information than the single modality.%本文介绍了一种新型的小动物四模态分子影像系统的研发。该系统集成了计算机断层成像（computed tomography, CT）、正电子发射断层成像（positron emission tomography, PET）、单光子发射计算机断层成像（single-photon emission computed tomography, SPECT）和荧光分子断层成像（fluorescence molecular tomography, FMT）四种模态。对小鼠肿瘤-炎症模型的成像结果显示，融合了各个模态的综合重建结果可以提供较单一模态更加丰富的结构、功能代谢信息。
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