目的研究PCNA与BCL-2的表达在大肠癌预后评估中的意义.方法用sABC免疫组化法分析3年随访期间大肠癌患者肠标本的PCNA与BCL-2的表达.结果PCNA在正常大肠黏膜中不表达而在大肠癌中呈阳性表达,PCNA与肿瘤的复发、患者的死亡时间、肿瘤分期和淋巴道转移呈正相关(P＜0.05),而与患者的年龄、性别和肿瘤部位呈负相关.BCL-2仅与肿瘤分期高度相关(P＜0.05),与复发时间、死亡时间、年龄、性别和肿瘤部位无关(P＞0.05).结论分析PCNA与BCL-2的表达对大肠癌的临床治疗和预后评估具有重要意义.%Objective:To investigate the prognostic evaluation of PCNA and BCL - 2 expression in patients with colorectal carcinoma. Methods: Utilizing sABC Immunohistochemical methods, PCNA and BCL- 2 expression of specimens from patients with colorectal carcinoma during a three- year follow- up were analyzed. Results: PCNA and BCL - 2 expression was negative in normal colorectal mucossae but positive in colorectal carcinoma. PCNA demonstrated a positive correlation (P＜ 0.05) with the recurrence and death time of patient, tumor stage and lymphatic metastasis, but a negative correlation with patient's age, gender and tumor location. BCL-2 only shared a highly positive correlation ( P ＜ 0.05) with tumor stage and no obvious correlation (P ＞ 0.05) with such factors as recurrence time, death time, age, gender and tumor location. Conclusions:PCNA and BCL - 2 expression analysis is of important value in clinical treatment and prognostic evaluation of colorectal carcinoma.
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