Objective: To provide a criterion for determining whether a mouse's health by analyzing the time-frequency local characteristics of nonlinear and unsteady mice blood spectrum signal. Methods: Collect the blood spectrum signal of the normal and liver damage mice by infrared spectrum method, then study the mice blood spectrum signal by Hilbert -huang transform method. Results:Initially formed criterion on judge whether there is hepatic injury in mice signal. Conclusion: Analysis method based on HHT in mice blood signal spectrum analysis can accurately determine the health of the mice and it provides a new method of analysis for noninvasive blood tests.%目的：对非线性、非稳态的小鼠血液光谱信号的时频局部特征进行分析，形成小鼠是否存在肝损伤的健康状况判断依据。方法：用近红外光谱法采集正常和肝损伤小鼠的血液指标的光谱信号，应用希尔伯特-黄变换(HHT)方法对信号进行研究。结果：初步形成了判断小鼠是否存在肝功损伤信号依据。结论：基于HHT的分析方法对小鼠血液光谱信号的分析能准确判断小鼠的健康状况，同时为利用近红外光谱法进行血液无创检测提供了一种新的分析方法。
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