目的 优化疱毒清洗液提取工艺并进行质量控制.方法 采用星点设计-效应面法,以疱毒清水提液中没食子酸及野黄芩苷含量为代表性指标,考查煎煮时间、加水量、提取次数三个因素对提取效果的影响,再经中试生产验证,筛选出疱毒清洗液最佳的水提工艺.结果 疱毒清洗液最佳水提工艺为加10倍量水,煎煮提取2次,每次125 min.结论 星点设计-效应面法优选的提取工艺重现性好,质量稳定,可作为疱毒清洗液的提取工艺.%Objective To optimize the extraction process of Paoduqinq Lotion and to control its quality.Methods Through central composite design and response surface methodology,using gallic acid and scutellarin content as the indicators,the effects of the amount of water,extraction time,extraction frequency on water extraction process were investigated.The best water extraction process of Paoduqinq Lotion was obtained and varified by pilot scale test.Results The best water extraction process of Paoduqinq Lotion was performed by extracting the decoction with 10 times the amount of water twice,125 min each time.Conclusion The optimized extraction process with good reproducibility and stable quality can be used as the extraction process of blister lotion.
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