Objective To explore the relationships between COMT Val158 Met gene polymorphism in patients with remitted late-onset depression (RLOD),volume of the encephalic regions and cognitive functions.Methods From May 2014 to May 2015,in Third Hospital of Huzhou,32 RLOD patients who met the DSM-Ⅳ criteria for major depressive disorder wre selected.The patients were divided into two groups:16 patients with Val homozygotes allele carriers and 16 patients with Met carriers according to COMT genotyping of the RLOD patients,and all subjects received the cognitive function test with the neuropsychological battery and the whole brain MRI scan;demographic data,HDRS scores,neural psychology test results were analyzed,a semiautomatic image analysis program developed by Chinese Academy of Sciences Institute of automation were applied to calculate the average volume of brain.Relationships between the average volume of Met allele carriers in RLOD patients and neural psychology test results were evaluated.Results There was significant difference in Digit Span Test between Val homozygotes and Met carriers (P ＜ 0.05).The white matter volume of left precuneus in RLOD patients with Met carriers was significantly smaller than those with Val homozygotes (P ＜ 0.001,uncorrected,voxel ＞ 100).There were no significant correlations between the white matter volume of the left precuneus and all neuropsychological tests in RLOD patients with Met carriers (P ＞ 0.05).Conclusion COMT Val158 Met gene polymorphism is associated with the white matter volume abnormality of left precuneus in the LOD patients.%目的 探讨恢复期晚发性抑郁症(RLOD)患者儿茶酚胺氧位甲基转移酶(COMT)Val158 Met基因多态性与脑区体积、认知功能的关系.方法 选择2014年5月～2015年5月湖州市第三人民医院收治的符合DSM-Ⅳ重性抑郁障碍诊断标准的RLOD患者32例,按照COMT基因类型,分为Val纯合子等位基因携带者(16例)和Met等位基因携带者(16例),分别检测认知功能头颅MRI检查.分析人口学资料、HDRS分值和神经心理学测试进行比较;以由中科院自动化研究所研发的半自动影像分析程序计算平均容积值;对携带有Met RLOD者体素集合的平均容积和神经心理学测试结果进行相关分析.结果 Val纯合子携带者和Met携带者间的数字广度测试的比较差异有统计学意义(P＜0.05);相对携带Val纯合子基因的RLOD患者,携带Met基因者的左楔前叶脑白质显著缩小(P＜ 0.001,未校正,体素值＞100);携带Met的RLOD者,其楔前叶脑白质容积同所有神经心理学测试结果间无明显相关性(P＞0.05).结论 COMT Val158 Met基因多态性与RLOD患者左楔前叶脑白质容积异常存在关联.
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