Objective To explore the efficacy and safety of Tranexamic Acid in treating irregular uterine bleeding secondary to Depot-medroxyprogesterone acetat.Methods From December 2015 to December 2016,in First Affiliated Hospital of Chinese Medical Sciences University,80 patients with irregular uterine bleeding secondary to Depotmedroxyprogesterone acetat treatment were recruited.According to random number table,they were divided into treatment group and placebo group with 40 eases in each group,and they were treated with Tranexamic Acid and placebo respectively.All patients were followed up for 4 weeks,the outcomes were evaluated by the number of blood termination within 7 days and 28-day bleeding-free days and side effects reports were observed by information table.Results One case of the placebo group lost during follow-up,33 cases (82.5％) in the treatment group and 10 eases (25.6％) in the placebo group stopped bleeding within 7 days after treatment initiation,the difference was statistically significant (P ＜ 0.01).The 28-day bleeding-free proportion in treatment group was (20.73±4.07) d,that in the placebo group was (11.90±5.78) d,the difference was statistically significant (P ＜ 0.01).One case of mild nausea was reported.Conclusion Tranexamic Acid is an effective and safe choice in dealing with irregular uterine bleeding secondary to Depotmedroxyprogesterone acetat treatment.%目的 探索使用氨甲环酸治疗狄波-普维拉(DMPA)所致的子宫不规则出血(IUB)的疗效与安全性.方法 选择2015年12月～2016年12月中国医科大学附属第一医院收治的80例DMPA所致IUB患者,采用块状随机法将其分为氨甲环酸5d治疗的治疗组和安慰剂5d治疗的安慰剂组,每组各40例.随访观察4周,通过患者汇报的IUB信息表观察患者的7d止血例数、28 d无出血时间及不良反应发生情况.结果 安慰剂组失访1例,治疗组中33例(82.5％)受试者用药后7d内止血;安慰剂组中10例(25.6％)受试者用药7d内止血,差异有统计学意义(P＜0.05).治疗组受试者28 d无出血时长为(20.73±4.07)d,安慰剂组为(11.90±5.78)d,差异有统计学意义(P＜0.05).治疗组1例患者有轻微恶心.结论 氨甲环酸治疗DMPA所致的IUB疗效显著,安全性好.
展开▼
