Objective To evaluate the relevance of epidermal growth factor (EGF) 61 A/G polymorphism and suscepti-bility of gastric cancer. Methods The database of PubMed, Medline, EMbase, CBM, CNKI, Wanfang and VIP pub-lished from constructing database to January 1, 2015 were searched, so as to collect case-control study about EGF61 A/G polymorphism and susceptibility of gastric cancer. Pooled odds ratios (OR) with 95%confidence intervals (95%CI) were calculated by the RevMan 5.2 and Stata 12.0 software. Results Six controlled clinical trials (1502 cases and 2762 con-trols) were enrolled. Meta-analysis showed that there were significant differences of relevance between EGF61 A/G polymorphism and susceptibility of gastric cancer in the three genetic models (dominant model: OR = 1.31, 95%CI:1.06-1.61; recessive model: OR =1.27, 95%CI:1.01-1.60; GG vs AA: OR = 1.39, 95%CI: 1.10-1.76), however, there was no significant difference between AG model and AA model (OR =1.23, 95%CI: 0.98-1.54). The subgroup analysis by ethnicity showed that EGF61 A/G polymorphism could increase the risk of gastric cancer of Asian population (dom-inant model: OR = 1.47, 95%CI: 1.13-1.91; recessive model: OR = 1.37, 95%CI: 1.16-1.60; GG v s AA: OR = 1.66, 95%CI: 1.27-2.17). However, it had no relevance with the risk gastric cancer of the white population. Conclusion Based on the current research results, EGF61 A/G polymorphism is associated with the susceptibility of gastric cancer, and EGF61 A/G polymorphism can increase the risk of gastric cancer in Asian population.%目的：评价表皮细胞生长因子(EGF)61 A/G基因多态性与胃癌易感性的关联性。方法计算机检索PubMed、Medline、EMbase、CBM、CNKI、万方和维普等数据库。检索时间从建库至2015年1月1日,收集EGF61 A/G基因多态性与胃癌易感性的病例对照研究。采用RevMan 5.2和Stata 12.0软件计算合并效用量OR及其95%CI。结果共纳入6个研究,其中有1502例患者,2762例对照者。 Meta分析结果发现,3个遗传模型中EGF61 A/G基因多态性与胃癌易感性的相关性差异均有统计学意义(显性模型：OR=1.31,95%CI：1.06~1.61；隐形模型：OR=1.27,95%CI：1.01~1.60；GG和AA：OR =1.39,95%CI：1.10~1.76),而在AG和AA遗传模型中,两者差异无统计学意义(OR =1.23,95%CI：0.98~1.54)。基于人种的亚组分析显示：EGF61 A/G基因多态性可增加亚洲人罹患胃癌的风险(显性模型：OR =1.47,95%CI：1.13~1.91；隐形模型：OR =1.37,95%CI：1.16~1.60；GG和AA：OR =1.66,95%CI：1.27~2.17),但与白种人群胃癌风险无明显相关。结论基于目前的研究结果,可以认为EGF61 A/G基因多态性与胃癌易感性相关,且EGF61 A/G基因多态性可增加亚洲人罹患胃癌的风险。
展开▼
