目的：系统评价阻塞性睡眠呼吸暂停(OSA)与射频消融术后心房颤动(AF)复发的关系,为消融术后AF复发的病因探索提供依据。方法计算机检索PubMed、Embase、Cochrane图书馆、中国期刊全文数据库、维普数据库、万方数据库关于OSA与射频消融术后AF复发的队列研究,采用RevMan 5.2软件进行Meta分析。结果纳入10篇队列研究,共计1571例患者。 Meta分析结果显示：OSA组术后AF复发的风险显著高于对照组(RR =1.36,95%CI：1.25~1.48,P <0.01)。按OSA诊断方法分组,亚组分析示,柏林问卷组的术后复发风险(RR =1.46,95%CI：1.31~1.63,P<0.01)高于多导睡眠监测仪组(RR =1.28,95%CI：1.13~1.45,P=0.0001)。结论患OSA的AF患者行导管消融术后AF复发的风险较对照组高,OSA是消融术后AF复发的危险因素。%Objective To review systematically the association between obstructive sleep apnea (OSA) and atrial fibril-lation (AF) recurrence after cather ablation, and to provide evidence for etiological research of AF recurrence after cather ablation. Methods The databases of PubMed, Embase, Cochrane library, CNKI, VIP Database and Wanfang Database were retrieved for selecting cohort studies about OSA and AF recurrence after cather ablation. A Meta-analy-sis was performed by RevMan 5.2 software. Results Ten cohort studies were included with a total of 1571 patients. The results of Meta-analysis showed that risk of AF recurrence after cather ablation in patients with OSA was significantly higher than that in control group (RR =1.36, 95%CI:1.25-1.48, P<0.01). Studies were grouped according to different diagnostic tools for OSA, and subgroup analysis showed that risk of AF recurrence after cather ablation in OSA diag-nosed by Berlin questionnaire (BQ) (RR =1.46, 95%CI:1.31-1.63, P<0.01) was higher than that in OSA diagnosed by polysomnography (RR =1.28, 95%CI:1.13-1.45, P=0.0001). Conclusion Patients with OSA have a greater risk of AF recurrence than those without OSA. OSA is a risk factor of AF recurrence after cather ablation.
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