2型糖尿病是一种常见的慢性代谢性疾病，胰岛素抵抗是其发生的主要原因之一，伴随着胰岛细胞功能下降，最终发展为2型糖尿病。胰岛素抵抗发生往往与肥胖症相关，由于体脂的堆积，肌肉和其他组织对葡萄糖的利用率降低，造成胰岛素抵抗和高胰岛素血症。脂肪组织能分泌多种细胞因子，包括脂联素、抵抗素、瘦素、内脂素、肿瘤坏死因子-α、白细胞介素-6、纤溶酶原激活物抑制剂-1、血管紧张素原和视黄醇结合蛋4等。这些脂肪因子参与各种机体的代谢过程，作为肥胖与胰岛素抵抗间的一种联系，在2型糖尿病的发生发展中发挥重要作用。%Type 2 diabetes is a common chronic metabolic disease, which always results from insulin resistance and islet function decline. Insulin resistance is often associated with obesity, because of the accumulation of body fat, mus-cle and other tissues reduce glucose utilization, resulting in insulin resistance and hyperinsulinemia. Adipose tissue can secrete a variety of cytokines, including adiponectin, resistin, leptin, visfatin, tumor necrosis factor-α (TNF-α), interleukin-6, plasminogen activator inhibitor-1, angiotensinogen and retinol binding protein 4, etc. These adipocy-tokines involves in body's metabolic processes, as a link between obesity and insulin resistance, play an important role in the development of type 2 diabetes.
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