Objective To observe the analgesic effect of basin inflammation enema method to Pelvic inflammatory disease, and the influence of immune function. Methods According to the table of random number method, the 60 patients were divided into treatment group and control group, 30 cases in each group. The treatment group was treated with retention enema of basin inflammation enema method. The control group was given oral ornidazole dispersible tablet. Clinical analgesic action, the level of peripheral blood T lymphocyte subsets before and after treatment, and the level change of cell factor of interleukin 2 (IL-2), interleukin 10 (IL-10) of peripheral blood in two groups were observed. Results After treatment, there were some significant differences between two groups. Compared with control group, the level of pain score of treatment group had declined obviously (P < 0.05). In analgesic effect, there were some significant differences (P< 0.05). And treatment group was better than Control Group. The total effective rate was 73.3% in control group, 86.7% in treatment group. In treatment group, the levels of CD4, CD4 /CD8 had raised than before (P < 0.05). The levels of CD4, CD4/CD8 had raised than before (P > 0.05) in control group, but the difference had no statistical significance. After treatment, the level of CD8 had declined (P < 0.05) and the differences of CD4, CD4/CD8, CD8 had statistical significance in two groups (P < 0.05). But the improvement in treatment group was better than that of control group. The levels of IL-2 and IL-10 had risen in two groups, but treatment group were better than that of control group (P < 0.05). Conclusion The analgesic effect of basin inflammation enema method to Pelvic inflammatory disease is obvious, and it can improve the immune function of patients.%目的 观察盆炎灌肠方保留灌肠治疗盆腔炎性疾病的镇痛作用及免疫功能的影响.方法将盆腔炎性疾病患者60 例随机分为2 组,治疗组30 例予盆炎灌肠方保留灌肠,对照组30 例予口服奥硝唑分散片.观察两组临床镇痛作用和治疗前后外周血的细胞因子白细胞介素-2(IL-2)、白细胞介素-10(IL-10)和外周血T淋巴细胞亚群水平的水平变化.结果治疗后治疗组患者的疼痛评分明显下降,优于对照组,两组有显著性差异(P < 0.05);止痛疗效对照组的总有效率为73.3%,治疗组为86.7%,治疗组优于对照组,有显著性差异(P ＜ 0.05).对照组治疗后CD4、CD4/CD8与本组治疗前比较升高,但差异无统计学意义(P ＞ 0.05),治疗组治疗后CD4、CD4 /CD8与本组治疗前比较升高(P ＜ 0.05);两组治疗后CD8 均较治疗前下降(均P ＜ 0.05);治疗后2组CD4、CD4/CD8 、CD8 组间比较有显著性差异(P ＜ 0.05),治疗组改善优于对照组.两组治疗后均能升高IL-2和IL-10(P < 0.05);组间比较,治疗组显著优于对照组(P < 0.05).结论盆炎灌肠方保留灌肠治疗盆腔炎性疾病的镇痛作用明显,并能有效改善患者的免疫功能.
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