Objective To investigate the influence of Compound Sodium Bicarbonate Injection on the brain function of patients after cardiopulmonary resuscitation.Methods 20 patients having received emergency cardiopulmonary resuscitation were selected and divided into the observation group and the control group,with 10 patients in each group.The observation group was given early active symptomatic and supportive treatment in addition to the Sodium Bicarbonate Injection treatment,while the control group was only given the active symptomatic and supportive treatment.The oxygen saturation,intracranial pressure,mean arterial pressure,blood gas analysis and Glasgow coma score of the patients 3 and 7 days after the resuscitation were observed.Results 3 days after the resuscitation,the observation group was not significantly different from the control group in the oxygen saturation,blood gas analysis,intracranial pressure,mean arterial pressure and Glasgow coma score (P ＞ 0.05).7 days after the resuscitation,the observation group was not significantly different from the control group in the oxygen saturation,blood gas analysis and intracranial pressure (P ＞ 0.05),but was significantly different in the mean arterial pressure and Glasgow coma score (P ＜ 0.05).Conclusion Compound Sodium Bicarbonate Injection has a good effect on the recovery of neurological function and life activity ability of patients after cardiopulmonary resuscitation,indicating certain protection effect on the brain function,thereby worthy of clinical application.%目的 探讨复方碳酸氢钠注射液对心肺复苏后患者脑功能的影响.方法 选取20例急诊心肺复苏后患者,将其分为观察组和对照组,各10例.观察组在早期给予积极对症支持治疗的同时,给予复方碳酸氢钠注射液治疗,对照组只给予积极的对症支持治疗.观察患者复苏后3d和7d的血氧饱和度、颅内压、平均动脉压、血气分析情况和格拉斯格昏迷评分等.结果 观察组复苏后3d的血氧饱和度、血气分析情况、颅内压、平均动脉压和格拉斯格昏迷评分与对照组比较,差异无统计学意义(P＞0.05)；观察组在复苏后7d的血氧饱和度、血气分析情况及颅内压与对照组比较,差异无统计学意义(P＞0.05),但在平均动脉压和格拉斯格昏迷评分方面,差异有统计学意义(P＜0.05).结论 复方碳酸氢钠注射液对心肺复苏后患者的神经功能恢复和生活活动能力恢复具有良好效果,说明其对脑功能保护有一定作用,值得在临床推广应用.
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