Objective To observe the curative effect and safety of Plavix combined with Aspirin in treating transient ischemic attack of vertebrobasilar system.Methods 120 patients with transient ischemic attack of vertebrobasilar system in the People's Hospital of Ba'nan District in Chongqing City from January 2010 to June 2012 were chosen.All patients were divided into two groups randomly,60 cases in treatment group were treated with Plavix combined with Aspirin,60 cases in control group were treated with Aspirin,the course of treatment was 4 weeks,all patients were followed-up for 3 months.Clinical therapeutic effect 3 months after treatment was evaluated; the platelet count,coagulation indexes and adverse reactions such as haemorrhage were observed and compared.Results The total effective rate in treatment group and control group were 95.0％ and 65.0％ respectively 3 months after the treatment,the differences were statistically significant different (P ＜ 0.05).The differences of platelet count,FIB,PT,TT and APTT in the two groups 3 months after the treatment were all not statistically significant different (all P ＞ 0.05); no adverse reactions such as haemorrhage were found during the course of treatment.Conclusion Plavix combined with Aspirin in treating transient ischemic attack of vertebrobasilar system has a good curative effect,it is safe and worthy of clinical promotion.%目的 观察硫酸氢氯吡格雷联合阿司匹林治疗椎-基底动脉系统短暂性脑缺血发作(TIA)的效果及安全性.方法 选择重庆市巴南区人民医院2010年1月～2012年6月椎-基底动脉系统TIA患者120例,随机分为两组,治疗组60例给予硫酸氢氯吡格雷联合阿司匹林治疗,对照组60例给予阿司匹林治疗,疗程均为4周,并随访3个月.于治疗后3个月评价临床治疗效果,比较两组血小板计数、凝血指标及出血等不良反应情况.结果 治疗后3个月,治疗组总有效率为95.0％,对照组总有效率为65.0％,两组比较差异有统计学意义(P＜0.05).治疗后3个月血小板计数、凝血酶时间、凝血酶原时间、纤维蛋白原、活化部分凝血活酶时间两组比较差异均无统计学意义(均P＞ 0.05);在治疗过程中未见出血等不良反应发生.结论 硫酸氢氯吡格雷联合阿司匹林治疗椎-基底动脉系统TIA具有良好的疗效,安全可行,值得临床推广.
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