Objective To evaluate the clinical efficacy of Seretide inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease with (AECOPD).Methods 60 patients with AECOPD were randomly divided into the treatment group and the control group,with 30 patients in each group.Both groups of patients were given oxygen uptake,anti-infection,cough relieving,expectoration elimination,airway expansion and other conventional treatment and the treatment group inhaled seretide inhalant (500 μg of Fluticasone Propionate or 50 μg of Salmeterol)twice per day for 10 days.Through observing the changes of lung function,blood gas,glycosylated hemoglobin (HbA1c),8 am fasting glucose (8 am FBG) and 2-hour postprandial blood glucose (2 h PG),the lung function indicators were evaluated and the clinical efficacy of seretide was observed.Results The FEV1/FVC,FEV1％ predicted value and PaO2 of each group significantly elevated compared to those before treatment (P ＜ 0.05); After treatment,the treatment group was higher than the control group in the FEV1/FVC and FEV1％ predicted value (P ＜ 0.05).The PaCO2 of each group significantly reduced compared to that before treatment (P ＜ 0.05); after treatment,the treatment group had significantly reduced PaCO2 compared to the control group (P ＜ 0.05).The changes of HbA1c,8 am FBG and postprandial 2 h PG were not significant between before and after treatment,without statistical significance (P ＞ 0.05).Conclusion Seretide powder inhalation is a safe and effective method for the treatment of AECOPD,providing a new treatment approach for the treatment of AECOPD.%目的 探讨临床上采用舒利迭吸入法治疗慢性阻塞性肺疾病急性发作期(AECOPD)的临床疗效.方法 采用完全随机分组的原则将60例AECOPD患者分为治疗组和对照组,每组30例,两组患者均给予吸氧、抗感染、止咳祛痰和扩张气道等常规治疗,治疗组在以上基础上吸入舒利迭吸入剂(丙酸氟替卡松500 μg或沙美特罗50μg),每日2次,两组疗程均为10d.通过观察两组患者治疗后肺功能、血气、糖化血红蛋白(HbA1c)、8 am空腹血糖(8 am FBG)及餐后2h血糖(2 h PG)的变化,评价患者肺功能指标,观察舒利迭临床疗效.结果 两组1秒用力呼出量(FEV1)/用力肺活量(FVC)、FEV1分别较治疗前明显升高(P＜0.05)；治疗后治疗组FEV1/FVC、FEV1％预计值分别高于对照组(P＜0.05).两组动脉血二氧化碳分压(PaCO2)较治疗前明显下降(P＜0.05);治疗后治疗组PaCO2较对照组下降显著(P＜0.05).两组治疗前后HbA1c、8 am FBG及餐后2h PG的变化不明显,差异无统计学意义(P＞0.05).结论 舒利迭粉吸入是治疗AECOPD安全有效的方法,为AECOPD提供了新的治疗方法和治疗途径.
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