Objective To explore the clinical significance in predicting the ovarian reserve by detecting serum levels of AMH and INHB. Methods On the third day of a spontaneous cycle, the serum levels of AMH, INHB, FSH were detected with enzyme linked immunosorbent assays (ELISA) and immunoenzymatic assay in 108 patients (37 patients with poor o-varian response, 71 patients with normal ovarian response), at the same day, AFC was determined by transvaginal color Doppler. Results The serum level of FSH [(9.89±1.01)mIU/mL] in the poor ovarian response group was significantly higher than that [(6.68±0.96)mIU/mL] in the normal ovarian response group (P < 0.05). The serum levels of AMH [(0.39±0.09)ng/L], INHB [(68.43±10.16)ng/L], AFC (5.98±0.96) in the poor ovarian response group were significantly lower than those [(1.51± 0.57)ng/L, (128.68±17.42)ng/L, (11.52±2.31)] in the normal ovarian response group (all P < 0.05). The serum levels of AMH and INHB were positively correlated with AFC (r = 0.62, 0.43, all P < 0.05) in the poor ovarian response group. Using area under the receiver operating curve (ROCAUC), the levels of AMH (ROCAUC=0.897, P < 0.05) and INHB (ROCAUC=0.886, P < 0.05) were found to be the best predictor of ovarian reserve. Conclusion The detection of serum levels of AMH and INHB are all sensitive in predicting the ovarian reserve.%目的 探讨血清抑制素B(INHB)及抗缪勒管激素(AMH)的检测对卵巢储备功能预测的临床价值.方法 采用酶联免疫吸附法(ELISA)及化学发光法对108例不孕症患者(卵巢低反应组37例、卵巢正常反应组71例)于月经第3天检测血清AMH、INHB及卵泡刺激素(FSH)水平,并采用彩色超声检查方式测量窦卵泡计数(AFC).结果 卵巢低反应组FSH水平[(9.89±1.01)mIU/mL]明显高于卵巢正常反应组[(6.68±0.96)mIU/mL],卵巢低反应组AMH水平[(0.39±0.09)ng/L]、INHB水平[(68.43±10.16)ng/L]及AFC[(5.98±0.96)个]明显低于卵巢正常反应组[(1.51±0.57) ng/L、(128.68±17.42)ng/L、(11.52±2.31)个],差异均有统计学意义(均P < 0.05);卵巢低反应患者AFC与血清AMH、INHB水平呈正相关(r = 0.62、0.43,均P < 0.05);AMH(ROCAUC=0.897,P < 0.05)及INHB(ROCAUC=0.886,P < 0.05)对卵巢储备功能的预测能力较强.结论 血清中AMH及INHB水平检测对卵巢储备功能的预测具有较高的临床价值.
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