目的 观察血脂变化在类风湿关节炎诊治中的临床价值.方法 86例类风湿关节炎(RA)患者,通过抗风湿药物和小剂量激素治疗1年后,对治疗前后的血沉、C反应蛋白、类风湿因子、总胆固醇、三酰甘油、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇进行检测,分析血脂变化在诊治中的价值.结果 类风湿关节炎患者治疗后血沉、C反应蛋白、总胆固醇都明显低于治疗前(P ＜ 0.05),而高密度脂蛋白胆固醇较治疗前有明显的升高(P ＜ 0.05).但治疗前后低密度脂蛋白胆固醇和三酰甘油变化不明显(P ＞ 0.05).血沉与高密度脂蛋白胆固醇呈负相关(P ＜ 0.05),C反应蛋白、类风湿因子与高密度脂蛋白胆固醇未出现相关性(P ＞ 0.05).结论 血脂变化在类风湿关节炎的诊治中具有重要价值,类风湿关节炎与脂代谢、炎症反应有着密切的关系.%Objective To observe the clinical value of blood lipid change in diagnosis and treatment of rheumatoid arthritis. Methods 86 patients who were diagnosed as rheumatoid arthritis received anti-rheumatoid drug and small doses of hormone treatment, after 1 year, ESR, CRP, rheumatoid factor, TC, TG, LDL-C and HDL-C were detected before and after treatment, blood lipid change of patients were analyzed for the value of diagnosis and treatment. Results After treatment, the patients with rheumatoid arthritis were significantly lower than before treatment on ESR, CRP, TC (P < 0.05), but HDL-C was significantly rise than before treatment (P < 0.05), LDL-C and TG had no significantly change than before treatment (P > 0.05). ESR and HDL-C had the negative correlation (P < 0.05). CRP, rheumatoid factor and HDL-C did not appear correlation (P > 0.05). Conclusion Blood lipid change has important value in the diagnosis and treatment of rheumatoid arthritis, rheumatoid arthritis has a close relationship with lipid metabolism and inflammatory responses.
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