Objective To investigate the influence of Ketogenic diet on rabbit spinal cord ischemia -reperfusion injury. Methods 45 male rabbits were randomly divided into three groups, group A was given sham-operated, group B was given normal diet (normal diet, ND) + ischemia-reperfusion, group C was given Ketogenic diet (Ketogenic diet, KD) after 6 weeks + is-chemia-reperfusion. B, C group were given ligation of rabbit abdominal aorta (A group weared tie line and was not connected ) 30 minutes, then reperfusion 48 hours, the three groups of neurological evaluation were observed, the neurons was his-tologicaly observed, the protection of KD on myocardial ischemia -reperfusion injury in rats was evaluated. Results Group A of neurological evaluation, histological observation of neurons were both normal. The neurological of group B was significantly disordered, neuronal cell morphology was abnormal. The level of neurological dysfunction, abnormal neuronal cell morphology of group C were lighter than those of group B. Conclusion The ischemia-reperfusion injury reduces after the Ketogenic diet intervention.%目的 探讨生酮饮食对兔脊髓缺血再灌注损伤的影响.方法 选用健康雄性兔45只,随机分为三组,A组行假手术,B组给予正常饮食(normal diet,ND)+缺血再灌注,C组生酮饮食(ketogenic diet,KD)6周后+缺血再灌注,B、C组结扎兔腹主动脉(A组只穿线不接扎)30 min后,再灌注48 h,观察三组神经功能评价、病理组织学观察神经元细胞,评价KD对兔心肌缺血再灌注损伤的保护作用.结果 A组神经功能评价、病理组织学观察神经元细胞正常.B组神经功能出现明显障碍,神经元细胞形态异常.C组神经功能障碍程度、神经元细胞形态异常较B组轻.结论 用生酮饮食干预后脊髓缺血再灌注损伤减轻.
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