Objective To summarize and discuss the clinical effect of double interventional therapy of intraesophageal stenting and chemotherapy via catheter lavage for the patients with advanced esophageal carcinoma. Methods 53 patients with advanced esophageal carcinoma treated by double interventional therapy in oncology department of our hospital from September 2005 to November 2010 were selected and followed-up, the average age of the patients was 58.9 years old. All cases manifested typical symptoms of advanced esophageal carcinoma diagnosed by X-ray esophagogram, CT detection, and histological cytologic examinations, and coincided with classification standard of UICC in 1987 and AJCC/UICC TNM classification standard of esophageal carcinoma. Intraarterial lavage chemotherapy was given 7 days after stenting. Results 53 patients with advanced esophageal carcinoma were given 65 stents in total, the successful rate was 100%; the patients were treated with intraarterial lavage chemotherapy 102 times, and the insertion successful rate of aimed-blood vessel was 87.25%; 49 cases had efficacy (excellent plus effective) in total, the efficacy rate was 92.45%. Conclusion Double interventional therapy can improve patient's food-intake condition and quality of life effectively, which has less suffering and few complications. It provides an effective therapeutic method for the patients with advanced esophageal carcinoma.%目的 探讨食管内支架置入并经导管灌注化疗术的双介入疗法治疗晚期食管癌的临床疗效.方法 选择2005年9月～2010年11月于我院肿瘤科进行双介入疗法治疗及随访的53例晚期食管癌患者,平均年龄58.9岁.全组病例均有晚期食管癌典型症状,并经X线食管造影、CT检查及组织学细胞学检查予以确诊,符合国际抗癌联盟(UICC)1987年标准分段及AJCC/UICC食管癌TNM分期标准.食管内支架置入术后7 d行导管动脉灌注化疗术.结果 53例晚期食管癌患者共置入内支架65枚,技术成功率达100%;导管动脉内灌注化疗术102次,靶血管插管成功率为87.25%(89/102);总有效(显效+有效)49例,总有效率达92.45%(49/53).结论 双介入疗法可有效改善患者进食状况,痛苦小,并发症少,提高了患者生活质量,为晚期食管癌患者提供了一种有效的治疗方法.
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