Objective To study the correlation factors of early hematoma enlargement in hypertensive cerebral hemorrhage. Methods 238 patients with hypertensive cerebral hemorrhage were divided into two groups, according to whether combined with early hematoma enlargement or not. The blood pressure level, hematoma form, bleeding site, liver function, PLT level, alcohol abuse, long-term use of Aspirin, and Mannitol application condition of the two groups were observed. Results Compared with the non-hematoma enlargement group, patients with irregular shape bleeding, bleeding site in the thalamus, intemperance, long-term use of Aspirin, early application of Mannitol in the hematoma enlargement group were more than those in the non-hematoma enlargement group (P < 0.01). The MSBP, MAP, ALT, GGT, PLT values was (188.76±32.29) mm Hg, (128.35±4.29) mm Hg, (56.26±10.83) U/L, (68.53±8.79) U/L, (124.53±35.74)xl07L respectively in the hematoma enlargement group, which was (164.63±27.16) mm Hg, (120.28+3.15) mm Hg, (32.75±9.38) U/L, (31.36±7.34) U/L, (216.29±53.14)xl09/L respectively in the non-hematoma enlargement group, the the differences were statistically significant (t = 6.724, 5.867, 4.194, 5.538, 7.145, P< 0.01). Conclusion Early hematoma enlargement in hypertensive cerebral hemorrhage is related with the blood pressure level, bleeding site, hematoma form, dysfunction of liver, PLT level, alcohol abuse, long-term use of Aspirin and early application of Mannitol, which should get the attention of the clinical worker and raise vigilance.%目的 探讨高血压脑出血早期血肿扩大的相关临床因素.方法 回顾性分析238例高血压脑出血患者,依据是否合并早期血肿扩大,分为血肿扩大及血肿未扩大两组;对比两组的血压水平、血肿形态、出血部位、肝功能、血小板水平、酗酒史、既往应用阿司匹林史及应用甘露醇时间等情况.结果血肿扩大组的不规则形态出血、出血部位为丘脑者、酗酒者、长期服用阿司匹林者及早期应用甘露醇者均较血肿未扩大组增多,差异有高度统计学意义(P < 0.01).血肿扩大组收缩压、舒张压、谷丙转氨酶、谷酰转肽酶、血小板值分别为(188.76±32.29)mm Hg、(128.35±4.29)mm Hg、(56.26±10.83)U/L、(68.53±8.79)U/L、(124.53±35.74)×109/L;血肿未扩大组为(164.63±27.16)mm Hg、(120.28±3.15)mm Hg、(32.75±9.38)U/L、(31.36±7.34)U/L、(216.29±53.14)×109/L,两组比较差异有高度统计学意义(t = 6.724、5.867、4.194、5.538、7.145,均P < 0.01).结论 高血压脑出血早期血肿扩大与血压水平、出血部位、血肿形态、肝功能异常、血小板数量、酗酒、长期服用阿司匹林及早期应用甘露醇有关,应得到临床工作者的重视,提高警惕.
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