肝纤维化是临床上常见的病理生理改变,其发生发展是个动态的过程,现已明确肝纤维化有可逆性.随着循证医学和现代生物技术的不断发展,对抗肝纤维化相关细胞因子的作用机制也得到逐步的阐明.现已明确,肝星状细胞(HSC)的活化和细胞外基质的不断生成和降解决定了肝纤维化的转归,在抗纤维化的众多细胞因子中,基质金属蛋白酶家族对细胞外基质的降解起着至关重要的作用.白细胞介素-10不仅可以使TGF-β1、EGF等细胞因子的表达下调,从而减少HSC细胞的活化与增殖,而且可以刺激基质金属蛋白酶的合成,进而增加细胞外基质的降解.本文将对基质金属蛋白酶和白细胞介素-10的特征及其在抗肝纤维化中的作用展开综述.%Hepatic fibrosis is a common pathophysiological change in clinic, its genesis and development is a dynamic process, now the reversibility of liver fibrosis is clear. With the continuous development of evidence-based medicine and modern biotechnology, the mechanism of cytokines that against the process of liver fibrosis has also been gradually clarified. Now it is clear that the activation of hepatic stellate cells (HSC) and the continuous generations and degradations of the extracellular matrix determine the outcome of liver fibrosis. Among the anti-fibrotic cytokines, matrix metalloproteinase family plays a vital role in the extracellular matrix degradation. Interleukin-10 can not only down-regulate the expression of TGF-β1 and EGF cytokines, thereby reducing the HSC cell activation and proliferation, but also stimulate the synthesis of matrix metalloproteinases that leads to increase the extracellular matrix degradations. This article summarizes the characteristics of matrix metalloproteinases and interleukin-10, and their role in the process of anti-fibrotic.
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