Objective: To observe the efficacy of Shexiang Baosin Pill (SXBXW) and Aspirin with Simvastatin together in the treatment of artherosclerosis plaque of the carotid artery for the aged hypertension. Methods: 186 aged hypertensions were confirmed to have artherosclerosis plaque on the carotid artery by Doppler ultrasonography examination. 96 cases (SXBXW group) were given SXBXW and Simvastatin, 90 cases (control group) were given Aspirin and Simvastatin, routine dose for 6 months. Before and after treatment, Doppler ultrasonography and laboratory tests were performed including CP, ACP, blood viscosity, electrocardiogram. Results: The ACP of SXBXW group was decreased significantly than that of the control group (ρ＜0.05). The blood viscosity was also improved significantly in the SXBXW group (ρ＜0.05). Conclusion: The effect of SXBXW with Simvastatin has a special effect for artheriosclerosis plaque than Aspilin combined with Simvastadin.%目的:探讨麝香保心丸与阿司匹林分别配伍辛伐他汀对老年高血压患者颈动脉粥样硬化斑块的疗效.方法:选择颈动脉彩色多普勒检查明确有颈动脉粥样斑块的患者186例,其中96例(观察组)给予常规剂量麝香保心丸加辛伐他汀,90例(对照组)给予常规量阿司匹林加辛伐他汀治疗,两组疗程均为6个月.记录治疗前后的颈动脉IMT、斑块数量和颈动脉粥样硬化斑块总面积(CPA),同时观察血压、心电图、凝血功能,血黏度及生化检查.结果:治疗后观察组患者粥样班块数量较对照组明显减少;CPA明显缩小(P<0.05),血黏度得到明显改善(P<0.05).结论:麝香保心丸与辛伐他汀对颈动脉斑块的治疗效果优于阿司匹林配伍辛伐他汀.
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