乳腺癌的发病往往是外界各种不良因素及个体基因长期共同作用的结果,在众多因素中基因多态性是造成个体差异非常重要的一方面.通过国内外的病例对照研究我们发现维生素D受体基因、胃蛋白酶原C基因及TP53基因多态性与乳腺癌相关研究是目前国外的研究热点.通过对维生素D受体基因、胃蛋白酶原C基因及TP53基因多态性的研究可使我们进一步了解乳腺癌的病因.%Breast carcinoma is a multifactor disorder, that is thought to result from an interaction between genetic background and environmental factors, among the many factors contributing to the individual difference, gene polymorphism is a matter of special importance. With the present situation and development of study of gene polymorphism, we find that the case-control study on the associations of genetic polymorphisms of vitamin D receptor, pepsinogen C and TP53 with the risk of breast cancer, which is becoming a hot point. Advance study on gene polymorphism of vitamin D receptor, pepsinogen C and TP53 can throw new light on the cause of the disease.
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