Chronic obstructive pulmonary disease (COPD) is characterized by obstructed airflow advanced gradually and reversed partly. It correlates to inflammatory reactions in lung induced by pernicious particulate material or gas. Many cells, cytokines and adhesion molecules participate in the progress of COPD. We focus on the effect and mechanism of IL-32, INF-γand IL-1β in COPD in this paper.%慢性阻塞性肺疾病(COPD)是一种以部分可逆的慢性气流受限、病变持续进展为特征的疾病状态,肺部有害气体和颗粒物介导的异常炎症反应与其发生、发展有密切联系.多种细胞、细胞因子、黏附分子参与了慢性阻塞性肺疾病的发生及发展.本文重点讨论IL-32、INF-γ、IL-1β等细胞因子在慢性阻塞性肺疾病中的作用及机制.
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