Objective: To explore the clinical efficacy of thansplantation of allograft bone and vascularized free fibular autograft for repairing large bone and soft tissues defects of lower extremities.Methods: 12 cases of patients with large bone and soft tissues defects of lower extremities underwent allograft bone and vascularized free fibular autograft from May 2005 to May 2009 were designed as observation group, 16 patients treated with vascularized free fibular autograft from 2000 to 2004 were selected as control group.Results: All the flaps were alive after follow-up 12 to 40 months.Grafted allograft had showed bone union 3 to 8 months after operation.It was 91.7％ and 80.7％ of the limb function recovered in two groups with significant difference (P＜0.01).The excellent and good rate of joint was 91.7％ (11/12) and 81.3％ (13/16), there was a significant difference in the two groups (P＜0.05).Conclusion: Thansplantation of allograft bone and vascularized free fibular autograft for repairing large bone and soft tissues defects of lower extremities can improve limb function and decrease disability rate with well union of allograft and autogenous bone.%目的:探讨在下肢软组织伴大段骨缺损患者中应用吻合血管腓骨皮瓣组合异体骨移植的l临床疗效.方法:选取2005年5月～2009年5月于我院住院治疗的12例下肢软组织伴大段骨缺损患者为观察组,采用吻合血管腓骨皮瓣组合异体骨移植治疗进行修复.选取2000～2004年行腓骨皮瓣治疗的16例患者为对照组.结果:所有患者随访12～40个月,所有皮瓣全部成活,术后3～8个月后异体骨与腓骨愈合.观察组Enneking评分显著优于对照组,两组肢体功能恢复(91.7% vs 80.7%),差异有高度统计学意义(P＜0.01);两组关节优良率分别为91.7%(11/12)、81.3%(13,16),差异有统计学意义(P＜0.05).结论:应用吻合血管腓骨皮瓣组合异体骨移植治疗下肢软组织伴大段骨缺损,自体骨与异体骨愈合良好,可改善患肢功能并减少伤残率.
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