Objective: To observe the efficiency of Epinephrine (low dosage continuous vein injection) combined with conventional therapy for refractory heart failure(RHF). Methods: 44 cases of patients with RHF were randomly divided in two groups, 22 cases in each group. Based on the conventional therapy, the patients of two groups were given Epinephrine (low dosage continuous vein injection) and Dopamine respectively. Heart rate, blood pressure, pulse oxygen saturation, urine volume and heart function were observed during the therapy period and all patients were underwent supersonic inspection before and after treatment. Results: Obvious efficiency rate and total efficiency rate of the patients in Epinephrine group were higher than Dopamine group, but the difference was no significant (P＞0.05). Heart output, cardiac index and left ventricle ejection fraction of the patients in Epinephrine group were higher and difference was significant (P＜0.01). Conclusion: The short-term application of low dosage of Epinephrine is beneficial for improving heart failure and helping for the patients to go through the critical days. The clinical effect of Epinephrine for refractory heart failure is better than Dopamine.%目的:观察在常规治疗的基础上,加用肾上腺素(小剂量静脉持续泵入)治疗顽固性心力衰竭的疗效.方法:将44例顽固性心力衰竭患者随机分为肾上腺素组和多巴胺组,每组各22例,两组在常规治疗基础上,分别使用微量泵静脉输注小剂量肾上腺素或多巴胺,治疗36～72 h.治疗期间观察心率(HR)、血压(BP)、脉搏血氧饱和度(spO2)、尿量及心功能情况,治疗前后行超声检测左室功能.结果:肾上腺素组显效率和总有效率高于多巴胺组,但差异无统计学意义(P>0.05),用药后肾上腺素组每分输出量(CO)、心脏指数(CI)和左室射血分数(LVEF)高于多巴胺组,差异有高度统计学意义(P<0.01).结论:短期静脉输注小剂量肾上腺素,在慢性心力衰竭加重时有助于改善患者心脏功能,能起到帮助患者渡过危险期的作用,疗效优于多巴胺.
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