目的:探讨治疗胃癌的最佳联合化疗方案.方法:120例中晚期胃癌患者按随机数字表法分为TPF组、FOLFOX组和HPLF组,每组各40例.比较近期疗效和毒性反应.结果:近期疗效,FOLFOX组(57.5%)＞HPLF组(47.5%)＞TPF组(35.0%),FOLFOX组与TPF组比较,差异有统计学意义(P＜0.05);毒性反应,三组均未发生Ⅳ级毒性反应,FOLFOX组神经毒性明显高于TPF和HPLF组,差异有统计学意义(均P＜0.05),其余毒性反应差异均无统计学意义(均P＞0.05).结论:FOLFOX方案治疗胃癌有效率高,毒性反应相对较轻,值得临床推广应用.%Objective: To investigate the best combination chemotherapy methods on gastric cancer. Methods: 120 cases of patients with mid and late gastric cancer were randomly divided into TPF group, FOLFOX group and HPLF group, with 40 cases in each group. The effcacy and toxic reaction were compared in the near future. Results: Near future efficacy, FOLFOX group (57.5％)＞HPLF group (47.5％)＞TPF group (35.0％), FOLFOX group compared with the TPF group, there was a significantly difference (P＜0.05); toxic reaction, grade Ⅳ toxicity did not occur in three groups, the neurotoxicity of FOLFOX group was significantly higher than that of the TPF group and HPLF group (all P＜0.05), the rest were not significantly different (all P＞0.05). Conclusion: FOLFOX method on gastric cancer has a higher effective rate, toxic reactions are relatively mild. It is worthy of clinical application.
展开▼
