Objective: To evaluate the treatment value of sustains inflation (SI) in acute respiratory distress syndrome (ARDS) Beagle dog after open endotrachel suctioning.Methods: Twelve oleic acid-induced ARDS canine models ventilated with mechanical ventilation support were randomized into two groups after stabilizing for 30 min.Non-SI-group: did not SI in ARDS Beagle dog after open endotrachel suctioning.SI-group: SI in ARS Beagle dog after open endotrachel suctioning.Oxygenation index, indexes of respiratory mechanics were obserced before sputum suction and 5 min, 15 min, 30 min after sputum suction.Results: A transient hypoxemia was worsen in 5 and 15 min after open endotrachel suctioning, but recovered rapidly in 30 min.However, there was no obvious hypoxemia worsen in SI-group.Partial pressure of oxygen in artery (PaO2) was higher than that in Non-SI-group at the time point of 5 or 15 min (P＜0.05).Furthermore, Static lung compliance was better at the time point of 5, 15 or 30 min after open endotrachel suctioning than before open endotrachel suctioning in SI-group (P＜0.05).Conclusion: SI in acute respiratory distress syndrome (ARDS) after open endotrachel suctioning can improve oxygenation and lung compliance.%目的:探讨控制性肺膨胀(SI)对Beagle犬急性呼吸窘迫综合征(ARDS)开放吸痰后的治疗效果.方法:选择共12只Beagle犬,利用油酸建立犬ARDS模型,接呼吸机予以基础通气,稳定30 min后随机进行两组吸痰.SI组吸痰后立即予以一次SI,非SI组吸痰后不予SI.监测吸痰前、吸痰后5 min、15 min、30 min的动脉血气、呼吸力学参数等.结果:非SI处理组ARDS吸痰后可能出现一过性的低氧血症加重,然而SI处理组在吸痰后低氧血症加重的现象并不明显.与非SI组比较,SI组动脉氧分压(PaO2)在5 min和15 min时间点上显著增高( P<0.05),SI组肺静态顺应性(Cst)在吸痰后5 min、15 min和30 min较吸痰前显著升高(P<0.05),并且在5 min和15 min时间点上高于非SI组(P<0.05).结论:SI能改善ARDS开放吸痰后肺的氧合指标,改善肺顺应性.
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