Objective To observe the clinical effect of the precision liver resection treatment for the intrahepatic bile duct lithiasis. Methods 120 cases of patients with the intrahepatic bile duct lithiasis were selected as the observation objects, and were randomly divided into the observation group and control group. The patients in the observation group did the precision liver resection treatment, and the patients in the control group did the nonregular hepatectomy treatment. Then the operation time, intraoperative blood loss, postoperative complications, hospitalization time and hospitalization expenses, and the changes of biochemical indexes before and after treatment of the two groups were compared. Results In the observation group, the operation time was (354.3±12.5)min, which was longer than that of the control group was (278.9±11.4)min; the intraoperative blood loss was (528.5±129.3)mL, which was less than that of the control group was (848.7±148.3)mL; the length of hospital stay was (15.3±1.1)d, which was shorter than the control group was (23.6±1.3)d;the hospitalization cost was (18734.5±1761.3) yuan, which was less than that of the control group was (31578.4±1524.2)yuan, the comparative difference were statistically significant (all P<0.05). The postoperative GGT、ALT、ALP、TBA and TBiL of the two groups were lower than preoperative, the comparative difference were statistically significant (all P<0.05). The postoperative GGT、ALT、ALP、TBA and TBiL of the Observation group were (89.9±13.4)U/L, (47.4±13.1)U/L, (115.2±33.1)U/L, (6.3±2.9)mmol/L, and (22.5±10.1)mmol/L, which were lower than that of the control group were (152.9±12.4)U/L, (67.1±13.0)U/L, (198.1±33.0)U/L, (26.2±2.6)μmol/L and (42.5±10.3)μm o l/L , the comparative difference were statistically significant (all P < 0.05). In the Observation group, 5 cases of patients had surgical complications, the incidence was 8.33%; in the control group, 13 cases of patients had surgical complications, the incidence was 21.67%. The complications incidence rate of the observation group was lower than that of the control group, the comparative difference was statistically significant (P<0.05). Conclusion The precision liver resection can be individualized surgical treatment according to the situation of intrahepatic bile duct stones in patients, and can significantly improve patients with cholestasis, shorten in-hospital time and reduce the economic burden and the incidence of postoperative complications.%目的：观察肝内胆管结石患者行精准肝切除术治疗的临床效果。方法选取我院收治的120例肝内胆管结石病患者为观察对象，随机均分为观察组和对照组，观察组患者行精准肝切除术治疗，对照组患者行非规则性肝切除术治疗，比较两组患者手术时间、术中出血量、术后并发症、住院时间以及住院费用的不同，和治疗前后生化指标的变化情况。结果观察组患者手术时间为（354.3±12.5）min长于对照组的（278.9±11.4）min，术中出血量为（528.5±129.3）mL小于对照组的（848.7±148.3）mL，住院时间为（15.3±1.1）d短于对照组的（23.6±1.3）d，住院费用为（18734.5±1761.3）元低于对照组的（31578.4±1524.2）元，差异均有统计学意义（均P＜0.05）。两组患者术后GGT、ALT、ALP、TBA和TBiL均低于术前，差异有统计学意义（均P＜0.05）。观察组患者术后GGT、ALT、ALP、TBA和TBiL分别为（89.9±13.4）U/L、（47.4±13.1）U/L、（115.2±33.1）U/L、（6.3±2.9）μmol/L和（22.5±10.1）μmol/L，低于对照组的（152.9±12.4）U/L、（67.1±13.0）U/L、（198.1±33.0）U/L、（26.2±2.6）μmol/L 和（42.5±10.3）μmol/L，差异有统计学意义（均P＜0.05）。观察组患者中出现手术并发症的有5例，发生率为8.33％，对照组患者中出现手术并发症的有13例，发生率为21.67％。观察组患者手术并发症发生率低于对照组，差异有统计学意义（P＜0.05）。结论精准肝切除可根据肝内胆管结石患者情况进行个体化手术治疗，可明显改善患者胆汁淤积情况，缩短患者住院时间，减轻患者经济负担，而且术后并发症发生率较低。
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