Objective To investigate clinical efficacy and security of ultroviolet A/riboflavin corneal collagen crosslinking to progressive keratoconus.MethodsTwenty-two eyes with progressive keratoconus were treated by Ultraviolet A/riboflavin corneal collagen crosslinking. To observe the reaction of cornea at postoperative first, third and 7th day,and follow-up 1-6 months,containing corneal conditions, corneal curvature and intraocular pressure. At postoperative 6 month corneal hysteresis and corneal resistance factor was compared with preoperations.Results There were varying degrees of corneal edema at post-operative 1 day, 3 day, 7 day and 1 month. Nerve plexus of corneal stroma decreased. Corneal edema was fading and the number of nerve plexus was restoring gradually at postoperative 3 months. The corneas were clear and the number of nerve plexus returned to the preoperative level. There was statistically significant in comparing corneal hysteresis and corneal resistance factor in pre-operation and post-operation(P<0.01). The change of corneal curvature was unobvious. The intraocular pressure was stable and without unusual changes. The vision improved a line than pre-operation.Conclusion Ultraviolet A/riboflavin corneal collagen cross linking is a secure and effective therapy and stop the development of progressive keratoconus with stable disease.%目的：探讨紫外光-核黄素角膜交联术对进展期圆锥角膜的临床疗效及安全性。方法对22眼进行紫外光-核黄素角膜交联术，观察术后1、3、7d角膜反应，术后1、3、6个月角膜情况，角膜曲率，眼压。第6个月时测量角膜滞后量（CH）和角膜阻力因子量（CRF）与术前对比。结果术后1、3、7d，1个月角膜基质有不同程度水肿，角膜基质神经丛减少，术后3个月水肿消退，神经丛数量逐渐恢复，术后6个月角膜透明，神经丛数量恢复到术前水平。手术前后角膜强度CH值和CRF值比较具有统计学意义（P＜0.01），术前术后角膜曲率变化不明显，眼压平稳，无异常波动，视力术前较术后6个月平均提高一行。结论紫外光-核黄素角膜交联术是一种有效而安全的治疗方法，使进展期圆锥角膜病程发展停止，病情趋于稳定。
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