Objective To investigate clinical effect of knee flushing combined with ozone injection in treatment of knee osteoarthritis.Methods 146 patients with knee osteoarthritis were selected in hospital from April 2011 to April 2014, who were randomly divided into two groups. 73 patients treated knee flushing as control group. 73 patients treated knee flushing combined with ozone injection as observation group. Treatment effect was compared between two groups.ResultsAfter treatment in two groups, pain improved significantly, while VAS score; IL-6; TNF-α;CRP decreased significantly, while Lysholm score increased significantly. Pain in observation group was significantly better than control group. VAS score; IL-6; TNF-α; CRP in observation group were significantly lower than control group. Excellent rate; Lysholm score in observation group were significantly higher than control group. Function improvement time; function recovery time in observation group were significantly earlier than control group. Hospitalization time in observation group was significantly less than control group. Differences were statistically significant (P<0.05). Conclusion Knee flushing combined with ozone injection is an effective method in treatment of knee osteoarthritis, which can significantly relieve pain, reduce inflammatory factor level, improve knee function, has significant clinical effect, worth of clinical use.%目的：探讨膝关节冲洗联合臭氧注射治疗膝骨性关节炎的临床效果。方法选取本院2011年4月～2014年4月诊治的膝骨性关节炎患者146例，采用随机数字表法分为两组，73例患者实施膝关节冲洗治疗为对照组，73例患者实施膝关节冲洗联合臭氧注射治疗为观察组，比较两组患者的治疗效果。结果治疗后，两组患者疼痛情况均明显改善，VAS评分、白介素-6、肿瘤坏死因子-α、C反应蛋白均显著降低，膝关节功能Lysholm评分均显著增加。观察组患者疼痛情况明显好于对照组，VAS评分、白介素-6、肿瘤坏死因子-α、C反应蛋白均明显低于对照组，优良率、膝关节功能Lysholm评分均明显高于对照组，功能改善时间、功能恢复时间均明显早于对照组，住院治疗时间明显少于对照组，差异均有统计学意义（P＜0.05）。结论膝关节冲洗联合臭氧注射是治疗膝骨性关节炎的有效方法，可明显减轻疼痛，降低炎症因子水平，提高膝关节功能，临床疗效显著，值得临床推广使用。
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