目的：探讨老年男性患者雄激素受体CAG基因多态性重复数对冠心病的发病风险影响。方法随机选择我院心血管内科收治的86例冠心病患者作为观察组，100例体检非冠心病患者作为对照组，采用聚合酶连反应（PCR）和直接测序法测定两组研究对象外周血雄激素受体CAG重复序列的数目，并采用多因素Logistic回归分析冠心病发病的危险因素。结果观察组与对照组在年龄、BMI、TT、E2四项指标上差异无统计学意义（P＞0.05）；但是在高血压、糖尿病、高血脂、糖尿病家族史、冠心病家族史、CAG重复数＜22、CAG重复数≥22指标上，两组具有明显的差异，且具有统计学意义（P＜0.05）；吸烟、高血压、糖尿病、高血脂、冠心病家族史、CAG重复数＜22是冠心病的危险因素；其中CAG重复数＜22是CAG重复数≥22患冠心病的危险度增加4.421倍。结论罹患冠心病的危险因素很多，雄激素受体CAG基因多态性重复数＜22是患冠心病的主要危险因素之一。%Objective To investigate the relationship of androgen receptor CAG repeat polymorphism and coronary artery disease in elderly men. Methods 86 cases of coronary artery disease patients were randomly selected as the observation group,and 100 cases of medical non coronary heart disease were selected as control group,who were treated in our hospital department of cardiovascular internal medicine. Results Investigation of androgen receptor CAG repeat sequence number of the two groups of subjects peripheral was determined by polymerase chain reaction (PCR) and direct sequencing method.Risk factors of coronary heart disease were analyzed by multivariate logistic regression analysis.The observation group and the control group were no significant difference in the four indicators of age,BMI,TT, E2(P > 0.05),but the hypertension,diabetes,hyperlipidemia,family history of diabetes,family history of coronary heart disease,CAG repeat numbers of < 22,CAG repeat number ≥ 22 of two groups had the obvious difference with statistical significance(P < 0.05).Smoking,hypertension,diabetes,hyperlipidemia,family history of coronary heart disease,CAG repeat number<22 were risk factors for coronary heart disease.Coronary heart disease risk of CAG repeat numbers < 22 was 4.421 times greater than that of CAG repeat numbers ≥ 22. Conclusion There are many risk factors of CHD.Androgen receptor gene CAG polymorphism repeat number < 22 is one of the major risk factors of coronary heart disease.
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