目的：探讨帕罗西汀对功能性消化不良（FD）患者的疗效及生活质量的影响。方法采用自身对照研究，选择符合罗马Ⅲ标准的36例FD患者，给予帕罗西汀治疗，疗程8周。FD患者的临床疗效和生活质量采用症状严重程度指数、症状频率指数、汉化版简明健康调查量表（SF-36）进行评分。结果36例均完成治疗，在治疗终点，患者的临床症状均有明显改善（P ＜0.01）；症状的严重程度指数（9.80±1.5 vs 5.48±0.84）和频率指数（9.60±1.6 vs 5.0±0.76）均有显著降低；在治疗的第4周和第8周，FD患者在生理功能、生理职能、躯体疼痛、活力、情感职能、精神健康、社会功能和总体健康8个维度，均较治疗前改善，差异有显著性，且在治疗的第8周，改善最为明显（P＜0.01）。结论帕罗西汀可以缓解FD患者临床症状，提高其生活质量。%Objective To evaluate the effect of paroxetine treatment on the quality of life in patients with functional dyspepsia.Methods A self-control study on paroxetine therapy for 8 weeks in patients with functional dyspepsia according to RomeⅢcriteria was perfomerd,the clinical outcomes were evaluated by scales changes of severity index of symptom,frequency of symptom,and Chinese version of the MOS 36-iten short form healthy survey(SF-36). Results All 36 cases completed therapy,at the end of treatment,clinical symptom in all patients were improved(P < 0.01). Comprison of the scores index of symptom, quality of life of FD at the end of treatment with that at basal level,index of severity(9.80±1.5 vs 5.48 ±0.84)and frequency(9.60±1.6 vs 5.0 ±0.76) of symptoms were subsided significantly (P < 0.01),The SF-36 scores in all dimensions including physical functioning,role of physical,vitality,pain,mental health,role of emotional,social functioning and general health in patients with functional dyspepsia were significantly higher in 4 or 8 weeks after treatment respectively,the most effective mprovement in the 8 week. Conclusion Paroxetine Improves the clinical symptoms and the quality of life in FD patients.
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