Objective To analyze postoperative prognosis related factors through following up liver cancer patients who did segmental liver resection combined with hepatic portal venous occlusion therapy. Methods Medical records and da-ta of patients for primary liver cancer by segmental liver resection and segmental portal vein obstruction in our depart-ment from January 2008 to January 2011 were analyzed. Ten possible risk factors were analyzed in Cox proportional hazard model. A mono factor and multi factor analysis was performed. Results The 3 years follow-up rate was 96.4%. The results showed that mono factor were tumor size, tumor number, liver cirrhosis, tumor thrombus, tumor envelope and distant metastasis were the factors associated with prognosis(P<0.05).The results of multi factor analysis and sin-gle factor were roughly the same. Conclusion The prognostic of patients for primary liver cancer by segmental liver re-section and segmental portal vein obstruction is focused on tumor size, tumor number, liver cirrhosis, tumor throm-bus, tumor envelope and distant metastasis. Tumor size, tumor number, liver cirrhosis,tumor thrombus and distant metastasis are the risk factors,but tumor envelope is the protective factor.%目的：通过对行肝段切除术结合肝段门静脉阻断术治疗的肝癌患者术后随访调查，分析术后预后相关因素。方法分析我科2008年1月~2011年1月行切除术结合肝段门静脉阻断术的肝癌患者病历和随访资料，以Cox比例风险模型对可能对术后预后有影响的相关因素10项进行单因素定量分析、多因素分析。结果患者的3年随访率为96.4%，单因素分析显示肿瘤大小、肿瘤数目、肝硬化、血管癌栓、肿瘤包膜、远处转移是与预后相关的因素(P<0.05)；多因素分析与单因素分析的结果大致相同。结论行肝段切除术结合肝段门静脉阻断术治疗的肝癌患者预后取决于肿瘤大小、肿瘤数目、肝硬化、血管癌栓、肿瘤包膜、远处转移等方面，肿瘤大小、肿瘤数目、肝硬化、血管癌栓、远处转移为危险因素，肿瘤包膜为保护性因素。
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