Objective To investigate the expression and clinical significance of midkine in cervical carcinoma. Meth-ods Immunohistochemical staining was performed on cervical cancer,chronic cervicitis and cervical intraepithelial neo-plasia in 180 cases selected and treated in our hospital from January 2011 to January 2015.Difference of MK among 3 kinds of disease was compared,positive expression rate of different pathological type,periodization,degree of differentia-tion and with or without lymph node metastasis in cervical carcinoma were compared. Results The positive expression rate of MK in issue for cervical cancer,chronic cervicitis and cervical intraepithelial neoplasia was 78.9%,8.9% and 11.1% respectively and positive expression rate of MK in cervical cancer was significantly higher than that of chronic cervicitis and cervical intraepithelial neoplasia (P<0.05).There was a statistical difference of positive expression rate of MK in cervical cancer with different clinical periodization,degree of differentiation and with or without lymph node metastasis (P<0.05). Conclusion The positive expression of MK in cervical cancer and pathological characteristics of cervical cancer are closely related,it is expected to become a potential analysis index for early diagnosis of cervical cancer.%目的：探讨中期因子(MK)在子宫颈癌中的表达及其临床意义。方法选取2011年1月~2015年1月本院收治的子宫颈癌、慢性宫颈炎和宫颈上皮内瘤样病变共180例进行免疫组织化学染色，比较MK在3种疾病组织中的差异及不同病理类型、分期、组织分化程度和有无淋巴转移子宫颈癌的MK阳性率。结果 MK阳性表达率在子宫颈癌、慢性宫颈炎和宫颈上皮内瘤样病变组织中分别为78.9豫、8.9豫、11.1豫，子宫颈癌的MK阳性表达率显著高于慢性宫颈炎和宫颈上皮瘤内瘤样病变(P<0.05)；不同临床分期、组织分化程度和有无淋巴结转移子宫颈癌的MK阳性率比较，差异有统计学意义(P<0.05)。结论 MK在子宫颈癌中的阳性表达与其病理特征有密切关系，有望成为对子宫颈癌早期诊断的一种潜在分析指标。
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