Objective To explore the effect of super-early stage thrombolysis of urokinase treating acute cerebral in-farction (ACI) in order to provide reference for the selection of clinical treatment plan. Methods 400 patients with ACI hospitalized in our department of neurology from January to December 2014 were selected.According to different thera-peutic regimens,they were divided into different groups.22 patients were given urokinase thrombolysis+routine treatment within 3 hours of attack in super-early stage thrombolysis group,21 patients were given urokinase thrombolysis+routine treatment after 3-6 hours attack in thrombolysis group,while control group was given routine treatment measures.The curative effect among 3 groups and neurological deficit scale score before and adter treatment. Results The total effec-tive rate in super-early stage thrombolysis group,thrombolysis group and control group was 90.9%,90.5%,and 57.7%respectively.Effect of super-early stage thrombolysis group and thrombolysis group didn’t display a statistical difference after comparison (P>0.05).However,the effect in these two groups were both superior to that of control group (P<0.05). Neurological deficit scale score in super-early stage thrombolysis group and thrombolysis group after 1 day,10 and 20 days treatment was obviously lower than that of control group respectively (P<0.05),while neurological deficit scale score in super-early stage thrombolysis group after 10 and 20 days treatment was obviously lower than that of throm-bolysis group (P<0.05). Conclusion In the treatment of ACI,super-early stage thrombolysis can remarkably improve ef-fect.Effect of improving neurologic function impairment is more obvious compared with conventional thrombolytic regi-men.It is worthy of expansion and application in clinic.%目的：探讨超早期尿激酶溶栓治疗急性脑梗死的效果，为临床治疗方案的选择提供参考。方法选取2014年1~12月在神经内科住院治疗的400例急性脑梗死患者，根据治疗方案不同进行分组，超早期溶栓组22例患者在发病3 h内给予尿激酶溶栓+常规治疗，溶栓组21例患者在发病后3~6 h给予尿激酶溶栓+常规治疗，对照组357例患者则单纯给予常规治疗措施。比较3组的疗效及治疗前后的神经功能缺损评分。结果超早期溶栓组的总有效率为90.9%，溶栓组为90.5%，对照组为57.7%，超早期溶栓组与溶栓组的疗效差异无统计学意义(P跃0.05)，但疗效均显著优于对照组(P<0.05)。超早期溶栓组、溶栓组治疗后1、10、20 d的神经功能缺损评分均显著低于对照组(P<0.05)，超早期溶栓组治疗后10、20 d的神经功能缺损评分显著低于溶栓组(P<0.05)。结论超早期尿激酶溶栓治疗急性脑梗死能显著提高效果，与常规溶栓方案比较，其改善神经功能缺损的效果更显著，值得临床推广应用。
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