Objective To analyze the clinical effect of concurrent chemo-radiotherapy and simple radiotherapy after high-risk cervical cancer operation to accumulate experience for improving the prognosis of patients. Methods 125 pa-tients with high risk cervical cancer treated in our hospital from October 2011 to May 2014 were selected as the re-search objects and divided into control group (n=52) and observation group (n=73) according to the wishe of patients. The patients of two groups were given radical operation of cervical cancer.Control group was given simple radiotherapy while observation group was given concurrent chemo-radiotherapy after operation. The clinical efficacy and the inci-dence rate of adverse reaction of two groups were statistically analyzed. Results The total effective rate of observation group was significantly higher than that of the control group (76.71%v s 51.92%,χ2=8.364,P<0.05).The incidence rate of toxic and side reaction and radioactive damage in observation group was higher that of the control group respectively, but there was no statistical difference (P>0.05). Conclusion For patients with high-risk cervical cancer,the concurrent chemo-radiotherapy after radical operation of cervical cancer is helpful to improve the effective rate with less adverse reaction.It is worth clinical promotion and application.%目的：分析高危宫颈癌术后同步放化疗与单纯放疗的临床效果，为改善患者预后积累经验。方法选取2011年10月~2014年5月本院收治的125例高危宫颈癌患者为研究对象，入院后根据患者意愿分为对照组(n=52)和观察组(n=73)。两组患者均给予宫颈癌根治术。对照组术后给予单纯放疗，观察组术后给予同步放化疗。统计、分析两组的临床疗效和不良反应发生率。结果观察组的总有效率明显高于对照组(76.71% vs 51.92%，χ2=8.364，P<0.05)；观察组的毒副反应发生率、放射性损害高于对照组，但差异均无统计学意义(P>0.05)。结论对于高危宫颈癌患者，宫颈癌根治术后同步放化疗有助于提高有效率，且不良反应少，值得临床推广应用。
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