Objective To analyze the clinical effect of single-nostril transsphenoidal approach surgery in the treatment of hypophysoma. Methods Clinical data of 108 patients with hypophysoma admitted into our hospital from July 2011 to July 2013 were retrospectively analyzed.They were divided into two groups according to different treatment plans,and there were 54 patients in each group.The patients given transcranial approach surgery were assigned to control group, and the patients given single-nostril transsphenoidal approach surgery were assigned to research group.Clinical effect and prognosis (recurrence rate and the incidence rate of complication) between two groups was compared respectively. Results Amount of bleeding was (85.46±13.62) ml and bleeding time was (87.32±14.54) min respectively in research group,and it was (132.46±16.58) ml and (128.42±12.37) min respectively in control group and there was a statistical difference of above-mentioned indexes between two groups (P<0.05);hospitalization time in research group [(6.85±0.68) d] was shorter than that of control group [(10.75±1.29) d] (P<0.05);total removal rate in research group was higher than that of control group (P<0.05).VAS score after 1 day and 3 days surgery in research group was significantly lower than that of control group respectively,and recurrence rate in research group (0) was lower than that of control group (11.11%),the total incidence rate of complication in research group was lower than that of control group (P<0.05). Con-clusion Single-nostril transsphenoidal approach surgery treating hypophysoma can improve the removal rate of tumor, and alleviate postoperative pain degree,and improve prognosis of patients.It has effectiveness and safety of clinical ap-plication.%目的：分析经单鼻蝶入路手术治疗垂体瘤的临床效果。方法回顾性分析2011年7月~2013年7月本院收治的108例垂体瘤患者的临床资料，按不同治疗方案分为两组，每组54例。行经颅入路术者为对照组，行经单鼻蝶入路术者为研究组，比较两组的临床疗效与预后情况(复发率、并发症)。结果研究组的出血量为(85.46±13.62)ml，出血时间为(87.32±14.54)min，对照组分别为(132.46±16.58)ml、(128.42±12.37)min，两组比较，差异有统计学意义(P<0.05)；研究组的住院时间为(6.85±0.68)d，短于对照组的(10.75±1.29)d(P<0.05)；研究组的全切除率高于对照组(P<0.05)。研究组术后1、3 d的 VAS评分均明显低于对照组，研究组的复发率为0，低于对照组的11.11%，总并发症发生率低于对照组(P<0.05)。结论经单鼻蝶入路手术治疗垂体瘤可显著提高肿瘤切除率，减轻患者术后疼痛程度并改善其预后，具有临床应用有效性与安全性。
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