OBJECTIVE:To observe analgesic effect and safety of Shixin buccal tablets on pericoronitis of wisdom tooth. METHODS:120 patients with pericoronitis of wisdom tooth were randomly divided into control group and observation group with 60 cases in each group. Control group received periodontal pocket irrigation combined with metronidazole;observation group was additionally given Shixin buccal tablets on the basis of control group,1 tablet/time,4 times/d. Clinical efficacy,medication compli-ance,pain score and ADR were compared between 2 groups. RESULTS:The effective rate of observation group(95.00%)was sig-nificantly higher than that of control group(73.33%),with statistical significance(P0.05);the pain score of observation group was significantly lower than that of control group,with statistically significant difference(P<0.05). No serious ADR was found in 2 groups. CONCLUSIONS:Shixin buccal tablets significantly alleviate the pain caused by pericoronitis of wisdom tooth.%目的：观察石辛含片用于智齿冠周炎患者的镇痛效果和安全性。方法：将120例智齿冠周炎患者按随机数字表法分为对照组和观察组，各60例。对照组患者接受冠周冲洗联合甲硝唑上药治疗；观察组患者在对照组治疗基础上加服石辛含片，每次1片，每天4次。比较两组患者临床疗效、用药依从性、疼痛计分及不良反应。结果：观察组患者临床有效率（95.00％）显著高于对照组（73.33％），差异有统计学意义（P＜0.05）；两组患者用药依从性比较差异无统计学意义（P＞0.05）；观察组患者疼痛计分显著低于对照组，差异有统计学意义（P＜0.05）。两组患者均未出现严重不良反应。结论：石辛含片对智齿冠周炎患者的镇痛效果显著。
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