OBJECTIVE:To observe the cerebral protective effects of dexmedetomidine in brain aneurysm surgery. METH-ODS:48 patients with intracranial aneurysm were randomly divided into observation group and control group,with 24 cases in each group. Observation group was given dexmedetomidine 1 μg/kg,pump time 10 min,at rate of 0.5 μg/kg;control group re-ceived constant volume of normal saline. Hemodynamic changes,the levels of S100β protein and neuron specific enolase (NSE) were compared between 2 groups. RESULTS:The heart rate and mean arterial blood pressure were more stable in the observation group after medication,with statistical significance(P<0.05). The serum level of S100β protein at the end of operation(T5),6 h after operation(T6),12 h after operation(T7),24 h after operation(T8)were(1.52±0.35)μg/L,(1.69±0.33)μg/L,(1.72±0.42)μg/L,(2.08±0.57)μg/L;the serum level of NSE were(10.9±1.2)ng/L,(13.5±1.5)ng/L,(16.8±2.8)ng/L and(19.7±4.3)ng/L in observation group;those were all lower than in control group,with statistical significance(P<0.05). CONCLUSIONS:Dexme-detomidine for cerebral aneurysm operation is helpful for hemodynamics stability,and result in lower S100β protein and NSE. So it is important for cerebral protection.%目的：观察右美托咪定在脑血管瘤手术中的脑保护作用。方法：选择颅内动脉瘤患者48例，按随机数字表法分为观察组和对照组，各24例。观察组患者麻醉诱导时给予右美托咪定1μg/kg，泵注时间10 min，然后以0.5μg/kg速度泵注；对照组患者给予等量生理盐水泵注。比较两组患者血流动力学变化及S100β蛋白、神经元特异性烯醇化酶（NSE）水平变化。结果：观察组患者给药后心率、平均动脉压较对照组更为平稳，差异有统计学意义（P＜0.05）；观察组患者手术结束时（T5）、手术结束6 h（T6）、手术结束12 h（T7）、手术结束24 h（T8）血清S100β蛋白和血清NSE水平分别为（1.52±0.35）μg/L和（10.9±1.2）ng/L、（1.69±0.33）μg/L和（13.5±1.5）ng/L、（1.72±0.42）μg/L和（16.8±2.8）ng/L、（2.08±0.57）μg/L和（19.7±4.3）ng/L，均低于对照组，差异有统计学意义（P＜0.05）。结论：右美托咪定用于脑血管瘤手术有助于血流动力学稳定，且S100β蛋白、神经元特异性烯醇化酶水平更低，对脑保护具有重要意义。
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