OBJECTIVE: To study the role of lipid-lowering and losing weight of Compound Citrus reticulata combinations (CPZHW) on the nutritional obese rats. METHODS: The nutritional obesity rat model was established and then divided into 6 groups, i.e. blank control group (constant volume normal saline), model group (constant volume normal saline), atorvastatin group (10 mg·kg‐1) and CPZHW low-dose, medium-dose and high-dose groups(600,300、 150 mg‐·kg~'). They were given drags intragas-trically once a day for 45 consecutive days. The contents of total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low density lipoprotein (LDL-C) as well as glucose tolerance in serum were assayed. The amount of increasing weight, food intake and utilization ratio, Lee's index, body-fat ratio,The epididymal fat pad weight, perirenal fat pad weight and the quantities of fat cell in a view were observed. RESULTS: Compared with model group, the body weight, ratio of body weight-lipid, epi-didymis, perinephric fat-pad of CPZHW high-dose, medium-dose and low-dose groups were decreased significantly (P0.05). CONCLUSION: CPZHW plays the role of lipid-lowering and losing weight on nutritional obese rats.%目的:研究复方陈皮组合物(CPZHW)对营养肥胖型大鼠的降脂减肥作用.方法:喂饲高脂饲料以复制营养性肥胖模型大鼠.实验分为空白对照(等容生理盐水)、模型(等容生理盐水)、阿托伐他汀(10 mg·kg-1)和CPZHW高、中、低剂量(600、300、150mg·kg-1)组,灌胃给药,每天1次,连续45 d.检测血清中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的含量和糖耐量,计算体重、摄食量、食物利用率、Lee's指数、脂/体比、附睾、肾周脂肪垫重和脂肪细胞数.结果:与模型组比较,CPZHW高、中、低剂量组体重、脂/体比、附睾、肾周脂肪垫重显著减少(P＜0.01或P＜0.05),大鼠血清TG含量显著降低(P＜0.01或P＜0.05),HDL-C含量显著升高(P＜0.01)；CPZHW高、中剂量组大鼠脂肪细胞数显著增加(P＜0.01或P＜0.05),CPZHW中剂量组大鼠Lee's指数显著降低(P＜0.01).各组糖耐量无显著性差异(P＞0.05).结论:CPZHW对营养肥胖型大鼠有降脂减肥的作用.
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