目的:制备夏天无总碱多囊脂质体,并进行体外特征评价.方法:以包封率为评价指标,以卵磷脂(PC)与药物、PC与三油酸甘油酯(TO)、PC与磷脂酰丝氨酸(PS)、PC与胆固醇(CH)的质量比为考察因素,用复乳法制备夏天无总碱多囊脂质体;并考察其形态、粒径和体外释放行为.结果:PC与药物、PC与TO、PC与PS、PC与CH的质量比分别为10:2、3:1、4:3、1:2.5,包封率可达(50±3)%;多囊脂质体呈球状体,平均粒径为22.0μm,在生理盐水中体外释放时间可持续2d.结论:该制备工艺稳定、可行.%OBJECTIVE: To prepare Corydalis decumbens total alkali multivescular liposomes and evaluate it in vitro. METHODS: C. decumbens total alkali multivescular iiposomes were prepared by multiple emulsion method with encapsulation efficiency as index and with ratio of phospgatidycholine (PC) to drugs, ratio of PC to triolein (TO), ratio of OC to phosphatidylserine (PS) and ratio of PC to cholesterin (CH) as factors. The morphology, particle size, release in vitro of preparation were evaluated. RESULTS: The ratio of PC to drug, ratio of PC to TO, ratio of PC to PS and ratio of PC to CH were 10:2,3:1,4:3,1:2.5. The encapsulation efficiency of optimized formulation was (50 ± 3) ％. The multivescular liposomes assumed as spherical with average particle diameter of 22.0 μm. The drug release duration in normal saline was 2 days. CONCLUSION: The preparation technology is stable and feasible.
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