OBJECTIVE: To explore how to provide the pharmaceutical care after carrying out the plasma concentration monitoring of valproic acid.METHODS: The pharmaceutical care records of 679 cases after plasma concentration monitoring of valproic acid were analyzed statistically.RESULTS: Monitoring results of 122 cases was not valid, accounting for 43.7％ of 297 cases(297/679).Clinical pharmacists provided pharmaceutical care in written for 75 cases and oral pharmaceutical care for 222 cases.It was suggested to adjust dosage, change the type of drugs and combine multiple drugs.Results of plasma concentration monitoring showed 84.4％ can be cured (103/122).19 cases were suggested to receive combined therapy because dosage limit induced the dose of valproic acid below 50～100 nag·L-l.CONCLUSION: It can improve therapeutic effect that clinical pharmacist provide pharmaceutical care after plasma concentration naonitoring of valproic acid%目的:探讨如何开展丙戊酸血药浓度监测后的药学服务.方法:对2007-2009年679例/次丙戊酸血药浓度监测后的药学服务记录进行调查、统计分析.结果:监测结果不在有效范围共122人,监测了297例/次,占43.7% (297/679),临床药师对其中75例/次给予书面药学服务意见,222例/次给予口头药学服务,提出了剂量调整、药物品种更换、联合用药等建议.最终84.4%(103/122人)监测结果处于治疗范围内,19人因受到丙戊酸服用最大剂量的限制未能达到50～100 mg·L-1的有效血药浓度,给予联合用药的药学建议.结论:临床药师于血药浓度监测后为患者提供药学服务,可以更好地提高治疗效果.
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