OBJECTIVE: To observe the therapeutic efficacy of telmisartan at different administration time in the treatment of non-dipper hypertension. METHODS: A total of 80 patients with mild to moderate essential hypertension (EH) were randomly divided into morning administration group and evening administration group. Both groups were given telmisartan. Morning administration group were treated with telmisartan 80 mg at 7 am in the morning once a day; evening administration group were treated with telmisartan 80 mg at 19 pm in the evening once a day. The change of ambulatory blood pressure was rechecked 12 weeks later. The diurnal rhythm of blood pressure was compared between 2 groups. RESULTS: The circadian rhythm of blood pressure in morning administration group was recovered in 20.0％ patients whose non-dipper hypertension returned into dipper hypertension, compared with 52.5％ in the evening group, and there was significant difference between two groups (P＜0.01). The systolic blood pressure (SBP) and diastolic blood pressure (DBP) in evening administration group from 5:00 to 9:00 were lower than in morning administration group (P＜0.05). CONCLUSION: Telmisartan at different administration time can effectively improve the diurnal rhythm of blood pressure in patients with non-dipper hypertension.%目的:观察替米沙坦不同时间给药治疗非杓型高血压的疗效.方法:80例非杓型轻、中度原发性高血压患者随机分为晨服组与晚服组,2组均服用替米沙坦.晨服组于7:00时给予替米沙坦(80 mg/片)1片,每日1次;晚服组于19:00时给予替米沙坦(80 mg/片)1片,每日1次.12周后复查动态血压,比较2组血压昼夜节律的变化.结果:晨服组将非杓型血压纠正为杓型血压恢复昼夜节律的比例为20.0%,而晚服组将非杓型血压纠正为杓型血压恢复昼夜节律的比例为52.5%,2组间差异有统计学意义(P<0.01).晚服组清晨时段(5:00-9:00)收缩压和舒张压显著低于晨服组(P<0.05).结论:对于非杓型高血压患者,时辰化服用替米沙坦可以更好地改善血压昼夜节律.
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