目的：探究盐酸氨溴索联合多索茶碱治疗慢性支气管炎急性发作期的临床效果。方法90例慢性支气管炎急性发作期患者,根据治疗方法的不同分为对照组(40例)和研究组(50例)。对照组给予盐酸氨溴索治疗,研究组在对照组治疗基础上联合多索茶碱治疗。比较两组治疗效果。结果研究组咳嗽消失时间、痰液恢复正常时间及湿啰音消失时间分别为(4.14±1.73)、(3.23±1.35)、(3.84±1.33)d,优于对照组的(7.36±1.44)、(5.77±1.48)、(6.26±1.65)d,差异均具有统计学意义(P<0.05)。研究组最大肺活量(FVC)、第一秒用力呼气容积(FEV1)、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、最大呼气中段流量(MMEF)指标优于对照组,差异均具有统计学意义(P<0.05)。结论盐酸氨溴索联合多索茶碱可缓解慢性支气管炎急性发作期患者临床症状及体征,且有效改善其肺功能,值得推广。%Objective To investigate clinical effect by ambroxol hydrochloride combined with doxofylline in the treatment of acute stage of chronic bronchitis. Methods A total of 90 patients with acute stage of chronic bronchitis were divided by different treatment measures into control group (40 cases) and research group (50 cases). The control group received ambroxol hydrochloride for treatment, and the research group received additional doxofylline. Curative effects were compared between the two groups. Results The research group had all shorter cough disappear time, sputum recovery time and moist rale disappear time as (4.14±1.73), (3.23±1.35), and (3.84±1.33) d than (7.36±1.44), (5.77±1.48), and (6.26±1.65) d in the control group, and the differences had statistical significance (P<0.05). The research group hadbetter forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), and maximum mid-expiratory flow (MMEF) respectively than the control group. Their differences all had statistical significance (P<0.05). Conclusion Combination of ambroxol hydrochloride and doxofylline can relieve clinical symptoms and vital signs in patients with acute stage of chronic bronchitis, along with effectively improved pulmonary function. This method is worth promoting.
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