Objective To understand distribution of common clinical pathogenic bacteria in Conghua district of Gaoming city, and to analyze its drug resistance, in order to provide reference for clinical treatment. Methods Drug sensitivity test was applied under national committee for clinical laboratory standards (NCCLS) criterion for 1270 strains of pathogenic bacteria as positive samples. Analysis of drug resistance was made according to drug sensitivity test outcomes. Results Among 1270 detected strains of pathogenic bacteria, there were 828 strains of gram-positive bacterium, accounting for 65.2%, and 442 strains of gram-negative bacterium, accounting for 34.8%. Gram-positive bacterium mainly included coagulase negative staphylococcus, followed by staphylococcus aureus and enterococcus faecalis. Gram-negative bacterium mainly included escherichia coli, followed by proteus mirabilis and Klebsiella pneumonia. Non-fermentative bacterial mainly included pseudomonas aeruginosa, followed by pseudomonas cepacia. There were totally 280 strains of fungus among the detection samples, and those funguses were the main pathogenic bacteria. Different bacteria had various drug resistance levels for corresponding antibiotics.Conclusion Conditioned pathogen has become more and more important as pathogenic bacteria, while fungus also has increasing trend. Control of drug resistance and rational antibiotics usage are the keys for successful infection treatment and drug resistance suspension.%目的：了解高明从化地区临床常见致病菌的分布，分析相关致病菌的耐药现状，为临床治疗提供依据。方法1270株细菌培养阳性标本的病原菌，按美国临床实验室标准化委员会(NCCLS)标准进行药物敏感试验，根据药敏结果进行耐药情况分析。结果在检出的1270例病原菌中，革兰阳性菌828株，占检出菌株的65.2%，革兰阴性菌442株，占检出菌株的34.8%。革兰阳性菌以凝固酶阴性葡萄球菌为主，其次是金黄色葡萄球菌、粪肠球菌等；革兰阴性菌以大肠埃希菌为主，其次是奇异变形杆菌、肺炎克雷伯菌等；非发酵菌以铜绿假单胞菌为主，其次是洋葱假单胞菌等。所有送检标本中，共检出真菌280株，成为生殖道送检标本中检出的重要病原菌。各种细菌对相应抗生素出现不同程度的耐药情况。结论条件致病菌成为越来越重要的病原菌，真菌感染有增多的趋势；掌握细菌耐药情况，合理规范使用抗生素，是感染治疗成功及延缓细菌出现耐药的关键。
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