Apolipoprotein B100 analysis in microchip with electrochemical detection

Cheng Cheng Liu; Yun Liu; Hui Xiang Wang; Yan Bo Qi; Peng Yuan Yang; Bao Hong Liu

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Apolipoprotein B100 analysis in microchip with electrochemical detection

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Apolipoprotein B100 (apoB-100) is a major protein of the cholesterol-rich low-density lipoprotein (LDL) and reflects a better assessment of total atherogenic burden to the vascular system than LDL. In this work, a simple and sensitive method has been developed to determine picoliter apoB-100s using the PMMA microfluidic chip coupled with electrochemical detection system. This method performs very well with a detectable linear range of 1-800 pg/mL and a detection limit of 1 pg/mL. A real serum sample has further been detected by this microchip-based biosensor. The results show that this kind of method is practicable and has the potential application in clinical analysis and diagnosis.

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《中国化学快报（英文版）》 |2011年第11期|1343-1346|共4页
作者
Cheng Cheng Liu; Yun Liu; Hui Xiang Wang; Yan Bo Qi; Peng Yuan Yang; Bao Hong Liu;
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Department of Chemistry and Institute of Biomedical Science, Fudan University, Shanghai 200433, China;

Department of Chemistry and Institute of Biomedical Science, Fudan University, Shanghai 200433, China;

Department of Chemistry and Institute of Biomedical Science, Fudan University, Shanghai 200433, China;

Department of Chemistry and Institute of Biomedical Science, Fudan University, Shanghai 200433, China;

Department of Chemistry and Institute of Biomedical Science, Fudan University, Shanghai 200433, China;

Department of Chemistry and Institute of Biomedical Science, Fudan University, Shanghai 200433, China;

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Apolipoprotein B100 analysis in microchip with electrochemical detection

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