The patient-derived tumor xenograft (PDTX) model is developed by implanting fresh tumor tissues into immunode-ficient mice and relying on the microenvironment provided by the mice. This model retains the principal pathophysiological characteristics, histological and phenotypic characteristics of donor tumors, maintains the matrix and stem cell composition of tumor cells, and replaces patients with preclinical studies to find a more reliable anti-cancer strategy. The incidence and mortality of gastrointestinal system tumors is extremely high. Now, more and more domestic and foreign experiments have been developed to build digestive system PDTX models and use them for the study of the corresponding tumors. This paper reviewed the latest application of PDTX model in gastrointestinal system tumor research, and the future development of tumor therapy is discussed and forecasted.%人源性肿瘤组织异种移植(PDTX)模型是通过将患者新鲜的肿瘤组织植入免疫缺陷小鼠,依靠小鼠提供的微环境生长.此模型保留了原代肿瘤的病理生理特性、组织学和表型特征,维持了肿瘤细胞的基质和干细胞组成,可代替患者进行临床前试验研究,以便找到更加真实可靠的抗癌策略.消化系统肿瘤是发病率和死亡率极高的疾病,目前已有多项国内外实验开发了消化系统PDTX模型并用于相应肿瘤的研究.本文就PDTX模型在消化系统肿瘤研究中的最新应用成果进行综述,并讨论和展望未来肿瘤治疗的发展方向.
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