目的 探讨参柴颗粒对晚期消化道肿瘤化疗常见不良反应的影响.方法 选择确诊为晚期消化道肿瘤患者64例,随机分为两组,每组32例.治疗组给予常规药物化疗联合参柴颗粒;对照组给予单纯化疗.治疗2个周期后,比较两组化疗前后血常规、免疫功能、生活质量的变化情况.结果 治疗组患者化疗后白细胞、中性粒细胞、血小板减少幅度较对照组小(P<0.05);治疗组患者化疗后T细胞CD4+、CD4+/CD8+、NKT细胞水平较对照组上升,差异有统计学意义(P<0.05);治疗组患者化疗后恶心呕吐、疼痛、食欲不振的改善率均高于对照组(P<0.05).结论 晚期消化道肿瘤化疗过程中联合应用参柴颗粒可以明显改善化疗常见不良反应.%Objective To investigate the influence of Shenchai keli on the common adverse reactions in chemotherapy of ad-vanced gastrointestinal tumors. Methods A total of 64 patients diagnosed with advanced gastrointestinal tumors were randomly divided into 2 groups. Thirty-two cases with Shenchai keli combined chemotherapy was treatment group, 32 cases with simple chemotherapy was control group. Blood routine examination, immune function, quality of life and the changes of the main indicators between two groups before and after chemotherapy were compared after 2 curative cycles. Results Decreasing of white blood cell, neutrophile granulocyte, blood platelet of treatment group were smaller than those of control group ( P<0. 05) . The proportion of CD4+T cell,CD4+/CD8+ and NKT cell of treatment group were higher than those of control group ( P<0. 05) . The improvement rate of nausea and vomiting, pain, loss of appetite in treatment group were higher than those in control group ( P<0. 05) . Conclusion Combined application of Shenchai keli and chemotherapy can significantly improve the common adverse reactions in advanced gastrointestinal tumors.
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