• 主题
高级搜索  >
历史搜索 清空历史
首页> 中文期刊> 《临床肿瘤学杂志》 >212例中国粘膜黑色素瘤患者的临床病理及预后分析

212例中国粘膜黑色素瘤患者的临床病理及预后分析

         
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective To determine the clinical presentation and outcome of patients with mucosal melanoma in China. Methods The elements of the database included basic demographic data of patients and prognosticators previously reported in literature , as well as the follow-up data including clinical outcome after treatment. The American Joint Committee on Cancer (AJCC) staging system (7th edition) was used for either clinical or pathological staging. Medical record of all patients with pathologically diagnosed mucosal melanoma consulted in our center since 2006 were retrieved and reviewed. Statistical analyses including survival and multivari-ate analyses of factors associated with survival were respectively performed by Kaplan-Meier method and Cox proportional hazard model. Results A total of 212 cases of mucosal melanoma were identified and reviewed. The mean age was 55. 8 years with male-to-female ratio 1:1.46. Head and neck was the most common site (45. 3% ). Bleeding was the most common initial symptom (40.6% ). In their primary lesion, 49. 5% of patients had definitive ulceration with a median thickness 3. 8mm (0.6-16.0mm). Lung (55. 2% ) was the most common metastatic site. The mainstay of therapy for mucosal melanoma was still surgery. The 1-, 2- and 5-year overall survival (OS) rates were 83.1% , 68. 3% and 26. 1 % , with a median OS of 33.0 months (95% CI: 22.9-43. 1 months). The results of multivariate analysis indicated that stage at diagnosis and serum lactate dehydrogenase (LDH) level were two significant predictive factors for OS, while the application of adjuvant therapy and LDH were the independent factors influencing disease free survival ( DFS). Conclusion Head and neck was the most common primary site of mucosal melanoma. In their primary lesion half of patients had definitive ulceration and got a much thicker tumor invasion. Clinical staging was significantly associated with clinical outcome in terms of OS, and the use of adjuvant therapy could significantly improve the DFS of patients with stage Ⅰ-Ⅲ%目的 分析粘膜黑色素瘤患者的临床表现、病理及预后情况.方法 收集2006年1月至2011年3月经病理确诊的212例粘膜黑色素瘤患者的临床病理资料,采用AJCC第7版黑色素瘤分期,并对其生存情况进行随访,用KaplanMeier法进行生存分析及Cox回归模型进行生存预测的多因素分析.结果 212例粘膜黑色素瘤患者的平均年龄为55.8岁,男女性别比为1:1.46,头颈部是最常见的原发部位(45.3％),出血是就诊时最常见的症状(40.6％).49.5％的患者就诊时原发灶存在明确的镜下溃疡,原发灶中位浸润深度为3.8mm(0.6～16.0mm).就诊时不同分期所占比例分别为:Ⅰ、Ⅱ期64.6％,Ⅲ期23.6％,Ⅳ期11.8％.肺是最常见的远处转移部位(55.2％).最主要的治疗方式仍为手术治疗.212例患者的1、2、5年生存率分别为83.7％、68.3％和26.1％,中位总生存时间为33.0个月(95％ CI:22.9～43.1个月).多因素分析显示,就诊时分期与血清乳酸脱氧酶(LDH)是影响总生存时间的独立预后因素,术后辅助治疗和LDH是影响无病生存时间的独立预后因素.结论 头颈部是粘膜黑素瘤最常见的原发部位,半数粘膜黑色素瘤患者就诊时原发灶存在溃疡并伴有较深的肿瘤浸润.就诊时分期与患者的总生存时间显著相关,术后辅助治疗可改善Ⅰ～Ⅲ期患者的无病生存时间.

著录项

  • 来源
    《临床肿瘤学杂志》 |2012年第7期|626-633|共8页
  • 作者

    崔传亮; 郭军; 李忠武; 连斌; 李思明; 唐碧霞; 迟志宏; 斯璐; 盛锡楠; 毛丽丽;

  • 作者单位

    100142 恶性肿瘤发病机制及转化研究教育部重点实验室;

    100142 北京 北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科;

    100142 北京大学肿瘤医院暨北京市肿瘤防治研究所病理科;

    100142 北京 北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科;

    100142 北京 北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科;

    100142 北京 北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科;

    100142 北京 北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科;

    100142 北京 北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科;

    100142 北京 北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科;

    100142 北京 北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 预后;
  • 关键词

    粘膜黑素瘤; 流行病学; 就诊时分期; 辅助治疗;

相似文献

  • 中文文献
  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号