Objective To explore the impact of LRP15 gene expression on relapse, classification and prognosis of leukemia. Methods Bioinformatics and free open gene chip data-set provided by gene expression omnibus (CEO) database and oncogenomics leukemia database were used to analyze the expression of LRP1S gene in leukemia patients. The relationship between LRP15 gene and relapse, classification and prognosis of leukemia was analyzed depending on LRP1S expression level. The prognosis of leukemia patients was analyzed by Kaplan-Meier method. Results Expression level of LRP1S in initial leukemia patients was significantly higher than that in relapsed leukemia patients (0. 204 ± 0. 053 vs. 0. 044 ± 0.035, P = 0.042 ). In cytogenetically normal acute myeloid leukemia (CN-AML) , it was higher in subtype Mo and M6 than that in subtype M, , M2, M4 and M, (P =0.003). The survival rate was significantly lower in all kinds of leukemia patients (P = 0. 009 ) with low-expression of LRP15 than those with high-expression of LRP15, including CN-AML patients (P = 0.030). Conclusion LRP15 may play an important role in relapse of leukemia. High levels of LRP1S expression may be especially associated with some subtypes of CN-AML. The expression of LRP1S is important in prognosis of leukemia.%目的 探讨白血病患者骨髓中LRP15基因表达水平与白血病复发的关系以及对白血病分型和预后的影响.方法采用生物信息学方法,利用瓦联网平台和开放性的基于基因芯片检测的基因表达数据库,比较LRP15基因在不同白血病患者骨髓中的表达情况,分析LRP15表达水平与白血病复发、分型和预后的关系.结果 白血病初发患者的LRP15表达水平明显高于复发患者(0.204±0.053 vs.0.044±0.035,P=0.042).在核型正常的急性髓系白血病(CN-AML)中,Mo、M6型的LRP15表达水平高于M1、M2、M4及M5型(P=0.003).LRP15表达水平与白血病患者的预后呈正相关(P =0.009),包括CN-AML (P =0.030).结论LRP15基因的表达水平与白血病复发密切相关,与CN-AML的某些亚型可能具有一定的相关性,对白血病患者的预后具有重要意义.
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